Mr Matsuev collaborates with the world's best known orchestras, such as the New York Philharmonic, Chicago Symphony, Berlin Philharmonic Orchestra, London Symphony, London Philharmonic, Leipzig Gewandhaus Orchestra, Bavarian Radio Symphony, National Symphony, Pittsburgh Symphony, WDR Symphony Cologne, BBC Symphony, Philharmonia Orchestra of London, Verbier Festival Orchestra Filarmonica della Scala, Accademia Nazionale di Santa Cecilia, Orchestre National de France, Orchestre de Paris, Orchestre Philharmonique de Radio France and Orchestre National du Capitole de Toulouse. He is continually re-engaged with legendary Russian orchestras.

Denis regularly appears with the most prominent conductors on the stage today, including Lorin Maazel, Valery Gergiev, Zubin Mehta, Mariss Jansons, Yuri Temirkanov, Kurt Masur, Paavo Jarvi, Leonard Slatkin, Myung-Whun Chung, Antonio Pappano, Semyon Bychkov, Ivan Fischer, Adam Fisher, Gianandrea Noseda, Jukka-Pekka Saraste, James Conlon, Mikhail Pletnev, Vladimir Fedoseyev, Vladimir Spivakov and Tugan Sokhiev.

Mr Matsuev is a frequent guest of renowned musical festivals such as the Ravinia Festival and the Hollywood Bowl in the United States, BBC Proms and Edinburgh International Festival in Great Britain, Schleswig-Holstein, Rheingau, Festspielhaus Baden-Baden in Germany, Chopin Festival in Poland, Maggio Musicale Fiorentino in Italy, Les Choregies d’Orange and Festival de la Rogue d’Antheron in France, Verbier and Montreux Festivals in Switzerland, Enescu Festival in Romania, Budapest Spring Festival in Hungary and Stars of the White Nights Festival in Russia.

Denis Matsuev's début recital at Carnegie Hall in November 2007 was recorded live by Sony BMG and released as an album entitled Denis Matsuev – The Concert at Carnegie Hall. The New York Times praised his performance; “…his poetic instincts held fast in tender moments, with trills as thrillingly precise as one might ever hope to hear.”

In December 2007, Alexander Rachmaninov, grandson of Sergei Rachmaninov, chose Mr Matsuev to perform and record unknown pieces on the composer's own piano at the Rachmaninov house Villa Senar in Lucerne. Subsequently, Sony BMG released Unknown Rachmaninoff, which has received strong positive reviews praising his execution and creativity. This unique program has been in high demand around the world. In October 2008, at the personal invitation of Alexander Rachmaninov, Denis Matsuev was named Artistic Director of the Sergei Rachmaninoff Foundation.

Mr Matsuev is the Artistic Director of Annecy Classics Festival in France, ‘Stars on Baikal’ Musical Festival in Irkutsk, Siberia, and the internationally recognized ‘Crescendo’ Festival. Additionally, Mr Matsuev is the president of the charitable Russian foundation ‘New Names’ that supports music education for children in regions of his native Russia.